ProTSAV: A protein tertiary structure analysis and validation server.
Biochim Biophys Acta
; 1864(1): 11-9, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26478257
ABSTRACT
Quality assessment of predicted model structures of proteins is as important as the protein tertiary structure prediction. A highly efficient quality assessment of predicted model structures directs further research on function. Here we present a new server ProTSAV, capable of evaluating predicted model structures based on some popular online servers and standalone tools. ProTSAV furnishes the user with a single quality score in case of individual protein structure along with a graphical representation and ranking in case of multiple protein structure assessment. The server is validated on ~64,446 protein structures including experimental structures from RCSB and predicted model structures for CASP targets and from public decoy sets. ProTSAV succeeds in predicting quality of protein structures with a specificity of 100% and a sensitivity of 98% on experimentally solved structures and achieves a specificity of 88%and a sensitivity of 91% on predicted protein structures of CASP11 targets under 2Å.The server overcomes the limitations of any single server/method and is seen to be robust in helping in quality assessment. ProTSAV is freely available at http//www.scfbio-iitd.res.in/software/proteomics/protsav.jsp.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Validação de Programas de Computador
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Software
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Proteínas
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Estrutura Terciária de Proteína
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Biologia Computacional
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article