[Genetic approach to hypertensive nephrosclerosis]. / Approccio genetico alla nefroangiosclerosi.

ABSTRACT

Several epidemiological and experimental studies suggest an important role of genetic factors in the pathogenesis of hypertensive nephrosclerosis. However, identification of susceptibility genes is difficult. The association between apolipoprotein L1 gene (APOL1) variants and non-diabetic chronic kidney disease in African Americans has modified the approach to hypertensive glomerular sclerosis, as a member of a single disease spectrum APOL1-associated FSGS.