Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914).
Antimicrob Agents Chemother
; 60(1): 621-3, 2016 01.
Article
em En
| MEDLINE
| ID: mdl-26482313
ABSTRACT
We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 µg/ml, 0.06 µg/ml, and ≤0.002 to 0.125 µg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 µg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Barbitúricos
/
DNA Girase
/
Farmacorresistência Bacteriana Múltipla
/
Inibidores da Topoisomerase II
/
Antibacterianos
/
Neisseria gonorrhoeae
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article