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Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Henriques, Alexandre; Croixmarie, Vincent; Priestman, David A; Rosenbohm, Angela; Dirrig-Grosch, Sylvie; D'Ambra, Eleonora; Huebecker, Mylene; Hussain, Ghulam; Boursier-Neyret, Claire; Echaniz-Laguna, Andoni; Ludolph, Albert C; Platt, Frances M; Walther, Bernard; Spedding, Michael; Loeffler, Jean-Philippe; Gonzalez De Aguilar, Jose-Luis.
Afiliação
  • Henriques A; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France.
  • Croixmarie V; Technologie Servier, Orleans, France.
  • Priestman DA; Department of Pharmacology, University of Oxford, Oxford, UK.
  • Rosenbohm A; Department of Neurology, University of Ulm, Ulm, Germany.
  • Dirrig-Grosch S; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France.
  • D'Ambra E; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France.
  • Huebecker M; Department of Pharmacology, University of Oxford, Oxford, UK.
  • Hussain G; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Department of Physiology, GC University, Faisalabad, Pakistan.
  • Boursier-Neyret C; Technologie Servier, Orleans, France.
  • Echaniz-Laguna A; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Hôpitaux Universitaires, Département de Neurologie, Strasbourg, France.
  • Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany.
  • Platt FM; Department of Pharmacology, University of Oxford, Oxford, UK.
  • Walther B; Technologie Servier, Orleans, France.
  • Spedding M; Les Laboratoires Servier, Suresnes, France and Spedding Research Solutions SARL, Le Vesinet, France.
  • Loeffler JP; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France.
  • Gonzalez De Aguilar JL; Université de Strasbourg, UMR_S 1118, Strasbourg, France, INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, gonzalez@unistra.fr.
Hum Mol Genet ; 24(25): 7390-405, 2015 Dec 20.
Article em En | MEDLINE | ID: mdl-26483191
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingolipídeos / Glucosiltransferases / Esclerose Lateral Amiotrófica Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingolipídeos / Glucosiltransferases / Esclerose Lateral Amiotrófica Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article