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Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns.
Zou, James Y; Park, Danny S; Burchard, Esteban G; Torgerson, Dara G; Pino-Yanes, Maria; Song, Yun S; Sankararaman, Sriram; Halperin, Eran; Zaitlen, Noah.
Afiliação
  • Zou JY; Microsoft Research, Cambridge, MA 02142; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142; jazo@microsoft.com.
  • Park DS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143;
  • Burchard EG; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
  • Torgerson DG; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
  • Pino-Yanes M; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
  • Song YS; Computer Science Division, University of California, Berkeley, CA 94720; Department of Statistics, University of California, Berkeley, CA 94720; Department of Integrative Biology, University of California, Berkeley, CA 94720;
  • Sankararaman S; Department of Genetics, Harvard Medical School, Boston, MA 02115;
  • Halperin E; Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69102, Israel.
  • Zaitlen N; Department of Medicine, University of California, San Francisco, CA 94143;
Proc Natl Acad Sci U S A ; 112(44): 13621-6, 2015 Nov 03.
Article em En | MEDLINE | ID: mdl-26483472
Nonrandom mating in human populations has important implications for genetics and medicine as well as for economics and sociology. In this study, we performed an integrative analysis of a large cohort of Mexican and Puerto Rican couples using detailed socioeconomic attributes and genotypes. We found that in ethnically homogeneous Latino communities, partners are significantly more similar in their genomic ancestries than expected by chance. Consistent with this, we also found that partners are more closely related--equivalent to between third and fourth cousins in Mexicans and Puerto Ricans--than matched random male-female pairs. Our analysis showed that this genomic ancestry similarity cannot be explained by the standard socioeconomic measurables alone. Strikingly, the assortment of genomic ancestry in couples was consistently stronger than even the assortment of education. We found enriched correlation of partners' genotypes at genes known to be involved in facial development. We replicated our results across multiple geographic locations. We discuss the implications of assortment and assortment-specific loci on disease dynamics and disease mapping methods in Latinos.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores Socioeconômicos / Hispânico ou Latino / Genética Médica / Relações Interpessoais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: Caribe / Mexico / Puerto rico Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores Socioeconômicos / Hispânico ou Latino / Genética Médica / Relações Interpessoais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: Caribe / Mexico / Puerto rico Idioma: En Ano de publicação: 2015 Tipo de documento: Article