Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts.

Liu, Zhanglong; Casey, Thomas M; Blackburn, Mandy E; Huang, Xi; Pham, Linh; de Vera, Ian Mitchelle S; Carter, Jeffrey D; Kear-Scott, Jamie L; Veloro, Angelo M; Galiano, Luis; Fanucci, Gail E

Liu, Zhanglong; Casey, Thomas M; Blackburn, Mandy E; Huang, Xi; Pham, Linh; de Vera, Ian Mitchelle S; Carter, Jeffrey D; Kear-Scott, Jamie L; Veloro, Angelo M; Galiano, Luis; Fanucci, Gail E.

Afiliação

Liu Z; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Casey TM; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Blackburn ME; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Huang X; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Pham L; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
de Vera IM; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Carter JD; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Kear-Scott JL; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Veloro AM; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Galiano L; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.
Fanucci GE; Department of Chemistry, University of Florida, PO BOX 117200, Gainesville, FL 32611-7200, USA. fanucci@chem.ufl.edu.

Phys Chem Chem Phys ; 18(8): 5819-31, 2016 Feb 17.

Article em En | MEDLINE | ID: mdl-26489725

Assuntos

Espectroscopia de Ressonância de Spin Eletrônica; Protease de HIV/química; HIV-1/química; Sequência de Aminoácidos; Clonagem Molecular; Resistência a Medicamentos; Ativação Enzimática/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Protease de HIV/genética; HIV-1/efeitos dos fármacos; Humanos; Modelos Moleculares; Conformação Proteica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protease de HIV / HIV-1 / Espectroscopia de Ressonância de Spin Eletrônica Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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