Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses.
J Virol
; 90(1): 616-23, 2016 01 01.
Article
em En
| MEDLINE
| ID: mdl-26491154
ABSTRACT
Coinfection of ferrets with H5N1 and pH1N1 viruses resulted in two predominate genotypes in the lungs containing surface genes of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic H1N1 2009 (pH1N1). Compared to parental strains, these reassortants exhibited increased growth and virulence in vitro and in mice but failed to be transmitted indirectly to naive contact ferrets. Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus Reordenados
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Infecções por Orthomyxoviridae
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Vírus da Influenza A Subtipo H1N1
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Virus da Influenza A Subtipo H5N1
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Coinfecção
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article