Expanding the scope of alkyne-mediated bioconjugations utilizing unnatural amino acids.
Chem Commun (Camb)
; 52(1): 88-91, 2016 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-26499242
ABSTRACT
The importance of bioconjugates within the field of chemistry drives the need for novel methodologies for their preparation. Well-defined and stable bioconjugates are easily accessible via the utilization of unnatural amino acids (UAAs). As such, we have synthesized and incorporated two new UAAs into green fluorescent protein, and optimized a novel Cadiot-Chodkiewicz bioconjugation, effectively expanding the toolbox of chemical reactions that can be employed in the preparation of bioconjugates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Fluorescência Verde
/
Alcinos
/
Aminoácidos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article