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The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome.
Lowrie, M; Garden, O A; Hadjivassiliou, M; Harvey, R J; Sanders, D S; Powell, R; Garosi, L.
Afiliação
  • Lowrie M; Davies Veterinary Specialists, Hitchin, UK.
  • Garden OA; Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire, UK.
  • Hadjivassiliou M; Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.
  • Harvey RJ; Department of Pharmacology, UCL School of Pharmacy, London, UK.
  • Sanders DS; Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.
  • Powell R; Powell Torrance Diagnostic Services, Higham Gobion, UK.
  • Garosi L; Davies Veterinary Specialists, Hitchin, UK.
J Vet Intern Med ; 29(6): 1564-8, 2015.
Article em En | MEDLINE | ID: mdl-26500168
BACKGROUND: Canine epileptoid cramping syndrome (CECS) is a paroxysmal movement disorder of Border Terriers (BTs). These dogs might respond to a gluten-free diet. OBJECTIVES: The objective of this study was to examine the clinical and serological effect of a gluten-free diet in BTs with CECS. ANIMALS: Six client-owned BTs with clinically confirmed CECS. METHODS: Dogs were prospectively recruited that had at least a 6-month history of CECS based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. Dogs were tested for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies in the serum at presentation, and 3, 6, and 9 months after the introduction of a gluten-free diet. Duodenal biopsies were performed in 1 dog. RESULTS: Serum TG2 IgA titers were increased in 6/6 BTs (P = .006) and AGA IgG titers were increased in 5/6 BTs at presentation compared to those of controls (P = .018). After 9 months, there was clinical and serological improvement in all BTs with CECS strictly adhering to a gluten-free diet (5/5). One dog had persistently increased antibody titers. This dog scavenged horse manure. On the strict introduction of a gluten-free diet this dog also had an improved clinical and serological response. The diet-associated improvement was reversible in 2 dogs on completion of the study, both of which suffered a relapse of CECS on the re-introduction of gluten. CONCLUSIONS: Canine epileptoid cramping syndrome in BTs is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Discinesias / Doenças do Cão / Dieta Livre de Glúten / Ração Animal Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Discinesias / Doenças do Cão / Dieta Livre de Glúten / Ração Animal Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article