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Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages.
Casero, David; Sandoval, Salemiz; Seet, Christopher S; Scholes, Jessica; Zhu, Yuhua; Ha, Vi Luan; Luong, Annie; Parekh, Chintan; Crooks, Gay M.
Afiliação
  • Casero D; Department of Pathology &Laboratory Medicine, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California, USA.
  • Sandoval S; Department of Pathology &Laboratory Medicine, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California, USA.
  • Seet CS; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Scholes J; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA.
  • Zhu Y; Department of Pathology &Laboratory Medicine, David Geffen School of Medicine University of California, Los Angeles, Los Angeles, California, USA.
  • Ha VL; Children's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Luong A; Children's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Parekh C; Children's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Crooks GM; Department of Pediatrics, Keck School of Medicine, University of Southern California Los Angeles, Los Angeles, California, USA.
Nat Immunol ; 16(12): 1282-91, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26502406
ABSTRACT
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes encoding previously unknown long non-coding RNAs (lncRNAs) were revealed through the analysis of these rare populations. Lymphoid commitment was characterized by lncRNA expression patterns that were highly stage specific and were more lineage specific than those of protein-coding genes. Protein-coding genes co-expressed with neighboring lncRNA genes showed enrichment for ontologies related to lymphoid differentiation. The exquisite cell-type specificity of global lncRNA expression patterns independently revealed new developmental relationships among the earliest progenitor cells in the human bone marrow and thymus.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Linhagem da Célula / Células Progenitoras Linfoides / Transcriptoma / RNA Longo não Codificante Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Linhagem da Célula / Células Progenitoras Linfoides / Transcriptoma / RNA Longo não Codificante Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article