Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.
Bioorg Med Chem Lett
; 25(23): 5566-9, 2015 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-26508550
ABSTRACT
Derivatives of phaeosphaeride A (PPA) were synthesised and characterised; then anti-cancer studies were carried out on the A549 cancer cell line. It was found that the acetyl derivative (compound 3) displayed comparable in vitro cytotoxicity to that of PPA (EC50=49±7 µM and EC50=46±5 µM, respectively), while chloroacetyl derivative 6 (EC50=33±7 µM) was found to have better efficacy towards the A549 cancer cell line.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos Heterocíclicos com Pontes
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article