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Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.
Abzianidze, Victoria V; Prokofieva, Daria S; Chisty, Leonid A; Bolshakova, Ksenia P; Berestetskiy, Alexander O; Panikorovskii, Taras L; Bogachenkov, Alexander S; Holder, Alvin A.
Afiliação
  • Abzianidze VV; Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, p/o Kuz'molovsky, Saint Petersburg 188663, Russian Federation. Electronic address: vvaavv@mail.ru.
  • Prokofieva DS; Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, p/o Kuz'molovsky, Saint Petersburg 188663, Russian Federation.
  • Chisty LA; Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, p/o Kuz'molovsky, Saint Petersburg 188663, Russian Federation.
  • Bolshakova KP; All-Russian Institute of Plant Protection, Federal Agency of Scientific Organizations, Pushkin, Saint Petersburg 196608, Russian Federation.
  • Berestetskiy AO; All-Russian Institute of Plant Protection, Federal Agency of Scientific Organizations, Pushkin, Saint Petersburg 196608, Russian Federation.
  • Panikorovskii TL; Department of Crystallography, Institute of Earth Sciences, Saint Petersburg State University, University Emb., 7/9., Saint Petersburg 199034, Russian Federation.
  • Bogachenkov AS; Department of Organic Chemistry, Institute of Chemistry, Saint Petersburg State University, Universitetsky Pr., 26, Saint Petersburg 198504, Russian Federation.
  • Holder AA; Department of Chemistry and Biochemistry, Old Dominion University, 4541 Hampton Boulevard, Norfolk, VA 23529, United States. Electronic address: aholder@odu.edu.
Bioorg Med Chem Lett ; 25(23): 5566-9, 2015 Dec 01.
Article em En | MEDLINE | ID: mdl-26508550
ABSTRACT
Derivatives of phaeosphaeride A (PPA) were synthesised and characterised; then anti-cancer studies were carried out on the A549 cancer cell line. It was found that the acetyl derivative (compound 3) displayed comparable in vitro cytotoxicity to that of PPA (EC50=49±7 µM and EC50=46±5 µM, respectively), while chloroacetyl derivative 6 (EC50=33±7 µM) was found to have better efficacy towards the A549 cancer cell line.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Bicíclicos Heterocíclicos com Pontes Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Bicíclicos Heterocíclicos com Pontes Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article