Allogeneic hematopoietic stem cell transplantation for Chediak-Higashi syndrome.
Pediatr Transplant
; 20(2): 271-5, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26511512
ABSTRACT
The clinical outcome of allogeneic HSCT was retrospectively analyzed in eight patients with CHS. In total, six of these eight patients are alive. Four of five patients transplanted with MAC achieved prompt engraftment, and three of the four patients, including two patients with AP before transplant, are alive without disease. In contrast, three patients transplanted with RIC without active AP disease achieved prompt engraftment and survive long term. RIC-HSCT might be an alternative treatment for CHS similar to other types of HLH, at least for patients without active AP disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante Homólogo
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Síndrome de Chediak-Higashi
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Transplante de Células-Tronco Hematopoéticas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article