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Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance.
Kirwan, Daniela E; Ugarte-Gil, Cesar; Gilman, Robert H; Caviedes, Luz; Rizvi, Hasan; Ticona, Eduardo; Chavez, Gonzalo; Cabrera, José Luis; Matos, Eduardo D; Evans, Carlton A; Moore, David A J; Friedland, Jon S.
Afiliação
  • Kirwan DE; Department of Medical Microbiology, St. George's Hospital, London, United Kingdom Infectious Diseases and Immunity, Imperial College London, London, United Kingdom dannikirwan@yahoo.com.
  • Ugarte-Gil C; Infectious Diseases and Immunity, Imperial College London, London, United Kingdom Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Gilman RH; Department of International Health, Johns Hopkins University, Baltimore, Maryland, USA Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Caviedes L; Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Rizvi H; Department of Cellular Pathology, Barts Health NHS Trust, London, United Kingdom.
  • Ticona E; Infectious Diseases and Tropical Medicine Unit, Hospital Nacional Dos de Mayo, Lima, Peru Universidad Nacional Mayor de San Marcos, Lima, Peru Universidad de San Martin de Porres, Lima, Peru.
  • Chavez G; Infectious Diseases and Tropical Medicine Unit, Hospital Nacional Dos de Mayo, Lima, Peru.
  • Cabrera JL; Department of Pulmonology, Hospital Daniel Alcides Carrión, Callao, Peru.
  • Matos ED; Universidad Nacional Mayor de San Marcos, Lima, Peru Infectious Diseases Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru.
  • Evans CA; Infectious Diseases and Immunity, and Wellcome Trust Centre for Global Health Research, Imperial College London, London, United Kingdom IFHAD: Innovation for Health and Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Moore DA; Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom.
  • Friedland JS; Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
J Clin Microbiol ; 54(1): 185-9, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26511739
ABSTRACT
In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose dos Linfonodos / Técnicas Bacteriológicas / Tuberculose Resistente a Múltiplos Medicamentos / Microscopia Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose dos Linfonodos / Técnicas Bacteriológicas / Tuberculose Resistente a Múltiplos Medicamentos / Microscopia Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article