Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7 µm optical coherence tomography.
Opt Lett
; 40(21): 4911-4, 2015 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-26512481
ABSTRACT
A spectral/Fourier domain optical coherence tomography (OCT) intravital microscope using a supercontinuum light source at 1.7 µm was developed to study subcortical structures noninvasively in the living mouse brain. The benefits of 1.7 µm for deep tissue brain imaging are demonstrated by quantitatively comparing OCT signal attenuation characteristics of cortical tissue across visible and near-infrared wavelengths. Imaging of hippocampal tissue architecture and white matter microvasculature are demonstrated in vivo through thinned-skull, glass coverslip-reinforced cranial windows in mice. Applications of this novel platform include monitoring disease progression and pathophysiology in rodent models of Alzheimer's disease and subcortical dementias, including vascular dementia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Iluminação
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Tomografia de Coerência Óptica
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Microvasos
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Substância Branca
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Microscopia Intravital
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Hipocampo
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article