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CXCR-4 Targeted, Short Wave Infrared (SWIR) Emitting Nanoprobes for Enhanced Deep Tissue Imaging and Micrometastatic Cancer Lesion Detection.
Zevon, Margot; Ganapathy, Vidya; Kantamneni, Harini; Mingozzi, Marco; Kim, Paul; Adler, Derek; Sheng, Yang; Tan, Mei Chee; Pierce, Mark; Riman, Richard E; Roth, Charles M; Moghe, Prabhas V.
Afiliação
  • Zevon M; Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ, 08854, USA.
  • Ganapathy V; Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ, 08854, USA.
  • Kantamneni H; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
  • Mingozzi M; Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ, 08854, USA.
  • Kim P; Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ, 08855, USA.
  • Adler D; Molecular Imaging Center, 41 Gordon Road (Suite D), Piscataway, NJ, 08854, USA.
  • Sheng Y; Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, 487372, Singapore.
  • Tan MC; Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, 487372, Singapore.
  • Pierce M; Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ, 08854, USA.
  • Riman RE; Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ, 08855, USA.
  • Roth CM; Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ, 08854, USA.
  • Moghe PV; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Small ; 11(47): 6347-57, 2015 Dec 16.
Article em En | MEDLINE | ID: mdl-26514367
Realizing the promise of precision medicine in cancer therapy depends on identifying and tracking cancerous growths to maximize treatment options and improve patient outcomes. This goal of early detection remains unfulfilled by current clinical imaging techniques that fail to detect lesions due to their small size and suborgan localization. With proper probes, optical imaging techniques can overcome this by identifying the molecular phenotype of tumors at both macroscopic and microscopic scales. In this study, the first use of nanophotonic short wave infrared technology is proposed to molecularly phenotype small lesions for more sensitive detection. Here, human serum albumin encapsulated rare-earth nanoparticles (ReANCs) with ligands for targeted lesion imaging are designed. AMD3100, an antagonist to CXCR4 (a classic marker of cancer metastasis) is adsorbed onto ReANCs to form functionalized ReANCs (fReANCs). fReANCs are able to preferentially accumulate in receptor positive lesions when injected intraperitoneally in a subcutaneous tumor model. fReANCs can also target subtissue microlesions at a maximum depth of 10.5 mm in a lung metastatic model of breast cancer. Internal lesions identified with fReANCs are 2.25 times smaller than those detected with ReANCs. Thus, an integrated nanoprobe detection platform is presented, which allows target-specific identification of subtissue cancerous lesions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ondas de Rádio / Receptores CXCR4 / Nanopartículas / Micrometástase de Neoplasia / Imagem Óptica / Raios Infravermelhos / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ondas de Rádio / Receptores CXCR4 / Nanopartículas / Micrometástase de Neoplasia / Imagem Óptica / Raios Infravermelhos / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article