Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.

Anastasiou, Vivian; Ninou, Elpiniki; Alexopoulou, Dimitra; Stertmann, Julia; Müller, Andreas; Dahl, Andreas; Solimena, Michele; Speier, Stephan; Serafimidis, Ioannis; Gavalas, Anthony

Anastasiou, Vivian; Ninou, Elpiniki; Alexopoulou, Dimitra; Stertmann, Julia; Müller, Andreas; Dahl, Andreas; Solimena, Michele; Speier, Stephan; Serafimidis, Ioannis; Gavalas, Anthony.

Afiliação

Anastasiou V; Paul Langerhans Institute Dresden of Helmholtz Center Munich at the University Clinic Carl Gustav Carus of TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Ninou E; DZD - German Centre for Diabetes Research, Germany.
Alexopoulou D; Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens, 11527, Greece.
Stertmann J; Deep Sequencing Group SFB655, BIOTEChnology Center (BioZ), TU Dresden, Dresden, Germany.
Müller A; Paul Langerhans Institute Dresden of Helmholtz Center Munich at the University Clinic Carl Gustav Carus of TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Dahl A; DZD - German Centre for Diabetes Research, Germany.
Solimena M; DFG-Center for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, TU Dresden, Dresden, Germany.
Speier S; Paul Langerhans Institute Dresden of Helmholtz Center Munich at the University Clinic Carl Gustav Carus of TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Serafimidis I; DZD - German Centre for Diabetes Research, Germany.
Gavalas A; Deep Sequencing Group SFB655, BIOTEChnology Center (BioZ), TU Dresden, Dresden, Germany.

Diabetologia ; 59(1): 139-150, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26518685

Assuntos

Aldeído Desidrogenase/genética; Aldeído Desidrogenase/fisiologia; Células Secretoras de Insulina/metabolismo; Família Aldeído Desidrogenase 1; Aldeído-Desidrogenase Mitocondrial; Alelos; Animais; Glicemia/análise; Diferenciação Celular; Glucose/metabolismo; Teste de Tolerância a Glucose; Glicogênio/metabolismo; Homeostase; Hiperglicemia/metabolismo; Ilhotas Pancreáticas/metabolismo; Fígado/metabolismo; Masculino; Camundongos; Camundongos Knockout; Estresse Oxidativo; Reação em Cadeia da Polimerase em Tempo Real; Fatores de Risco; Células-Tronco/citologia; Transcriptoma

Palavras-chave

Aldehyde dehydrogenase; Beta cell development; Beta cell dysfunction; Beta cell transcriptome; Diabetes risk factor; Hyperglycaemia; Insulin secretion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aldeído Desidrogenase / Células Secretoras de Insulina Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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