[The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease].
Sheng Li Ke Xue Jin Zhan
; 46(3): 180-4, 2015 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-26521482
ABSTRACT
Both iron and alpha-synuclein accumulation are one of hallmarks of Parkinson's disease (PD). Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation. Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation. Also, alpha-synuclein regulates iron metabolism through its ferrireductase activity. In this review, we will describe the roles of iron and alpha-synuclein in PD pathogenesis, and the mechanisms of iron and alpha-synuclein interaction.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article