The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.

Almahariq, Muayad; Mei, Fang C; Cheng, Xiaodong

Almahariq, Muayad; Mei, Fang C; Cheng, Xiaodong.

Afiliação

Almahariq M; Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Mei FC; Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Cheng X; Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA xiaodong.cheng@uth.tmc.edu.

Acta Biochim Biophys Sin (Shanghai) ; 48(1): 75-81, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26525949

Assuntos

Fatores de Troca do Nucleotídeo Guanina/metabolismo; Neoplasias/metabolismo; Animais; Apoptose; Movimento Celular; Proliferação de Células; AMP Cíclico/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; GTP Fosfo-Hidrolases/metabolismo; Humanos; Imunoterapia/métodos; Camundongos; Metástase Neoplásica; Transdução de Sinais

Palavras-chave

EPAC1; PKA; cancer cAMP; therapeutic target

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Troca do Nucleotídeo Guanina / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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