Dual Catalytic Decarboxylative Allylations of α-Amino Acids and Their Divergent Mechanisms.
Chemistry
; 21(51): 18589-93, 2015 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-26526115
ABSTRACT
The room temperature radical decarboxylative allylation of N-protected α-amino acids and esters has been accomplished via a combination of palladium and photoredox catalysis to provide homoallylic amines. Mechanistic investigations revealed that the stability of the α-amino radical, which is formed by decarboxylation, dictates the predominant reaction pathway between competing mechanisms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
Aminas
/
Aminoácidos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article