A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations.
Angew Chem Int Ed Engl
; 55(1): 164-8, 2016 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-26530026
ABSTRACT
We demonstrate the use of two different wavelength ranges of excitation light as inputs to remotely trigger the responses of the self-assembled DNA devices (D-OR). As an important feature of this device, the dependence of the readout fluorescent signals on the two external inputs, UV excitation for 1â
min and/or near infrared irradiation (NIR) at 800â
nm fs laser pulses, can mimic function of signal communication in OR logic gates. Their operations could be reset easily to its initial state. Furthermore, these DNA devices exhibit efficient cellular uptake, low cytotoxicity, and high bio-stability in different cell lines. They are considered as the first example of a photo-responsive DNA logic gate system, as well as a biocompatible, multi-wavelength excited system in response to UV and NIR. This is an important step to explore the concept of photo-responsive DNA-based systems as versatile tools in DNA computing, display devices, optical communication, and biology.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Fótons
/
Computadores Moleculares
/
Lógica
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article