Emerging Treatments for Neuropathic Pain.
Curr Pain Headache Rep
; 19(12): 56, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26530058
ABSTRACT
Neuropathic pain is a series of well-known conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of the pathophysiology of neuropathic pain, previously unexplored therapies have been used with encouraging results. As such, Acetyl-L-carnitine (ALC), Alpha-lipoic-acid (ALA), cannabinoids, Clonidine, EMA401, Botulinum Toxin type A, and new voltage-gated sodium channel blockers, can be cited. Furthermore, new modalities in neuromodulation such as high-frequency spinal cord stimulation, burst stimulation, dorsal root ganglion stimulation, transcranial direct current stimulation, and many others have been showing exciting results. Besides, changing paradigms may occur with the advent of optogenetics and a better understanding of epigenetic regulation. This article reviews the published literature on the treatment of NP. Despite the interesting results, randomized controlled trials are demanded for the majority of the therapies previously mentioned.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nootrópicos
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Estimulação da Medula Espinal
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Estimulação Transcraniana por Corrente Contínua
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Gânglios Espinais
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Analgésicos
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Neuralgia
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Fármacos Neuromusculares
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article