Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells.
J Neuroimmunol
; 288: 47-55, 2015 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-26531694
ABSTRACT
Studies in multiple sclerosis have demonstrated that normal-appearing white matter can harbor pathological changes. Here we investigated the effects of neuroinflammation, modeled by experimental autoimmune encephalomyelitis (EAE) on neural stem/progenitor cells (NPCs) located distally to inflammatory foci. We observed that EAE-derived NPCs had a lower capacity to differentiate into oligodendrocytes and an increased neuronal differentiation than control NPCs. This finding was corroborated with changes in gene expression of early differentiation genes. We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
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Encefalomielite Autoimune Experimental
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Células-Tronco Neurais
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Inflamação
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article