Plasma MASP-1 concentration and its relationship to recovery from coronary artery lesion in children with Kawasaki disease.
Pediatr Res
; 79(2): 301-7, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26536449
ABSTRACT
BACKGROUND:
This study investigated prognostic factors for early recovery of coronary artery lesion (CAL) in children with Kawasaki disease (KD).METHODS:
Patients hospitalized for KD were enrolled less than 2 wk from the onset of illness and divided into two groups KD with CAL and KD without CAL. The CAL group was further divided into two subgroups according to the degree of CAL mild (n = 31) and moderate/severe (n = 6) and further divided into two subgroups according to the age younger than 1 y (n = 9) and older than 1 y (n = 28). Lectin pathway-related factors MASP-1, CD59, and C5b-9 were measured, along with C-reactive protein, white blood cell counts, erythrocyte sedimentation rate, and platelet count. Patients were followed up for 3 mo. Correlation between the measured factors and the length of time of recovery from CAL was analyzed.RESULTS:
Plasma concentrations of MASP-1 in the CAL group were significantly lower than those without CAL. MASP-1 and gender positively correlated with the recovery time of CAL. There was no difference in MASP-1 between mild and moderate/severe CAL. At 3-mo follow-up, there was a positive correlation between plasma MASP-1 concentration and recovery time of the patients with CAL older than 1 y.CONCLUSION:
Plasma MASP-1 concentration at the early stage of KD is predictive of length of time of recovery from CAL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Serina Proteases Associadas a Proteína de Ligação a Manose
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Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article