Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts.

ter Weele, Eva J; Terwisscha van Scheltinga, Anton G T; Kosterink, Jos G W; Pot, Linda; Vedelaar, Silke R; Lamberts, Laetitia E; Williams, Simon P; Lub-de Hooge, Marjolijn N; de Vries, Elisabeth G E

ter Weele, Eva J; Terwisscha van Scheltinga, Anton G T; Kosterink, Jos G W; Pot, Linda; Vedelaar, Silke R; Lamberts, Laetitia E; Williams, Simon P; Lub-de Hooge, Marjolijn N; de Vries, Elisabeth G E.

Afiliação

ter Weele EJ; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Terwisscha van Scheltinga AG; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Kosterink JG; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Pot L; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Vedelaar SR; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Lamberts LE; Department of Pharmacy, Section of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, Netherlands.
Williams SP; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Lub-de Hooge MN; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
de Vries EG; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Oncotarget ; 6(39): 42081-90, 2015 Dec 08.

Article em En | MEDLINE | ID: mdl-26536664

Assuntos

Anticorpos Monoclonais/farmacocinética; Proteínas Ligadas por GPI/antagonistas & inibidores; Imunoconjugados/farmacocinética; Neoplasias Pancreáticas/metabolismo; Animais; Anticorpos Monoclonais/imunologia; Benzenossulfonatos/química; Benzenossulfonatos/farmacocinética; Linhagem Celular Tumoral; Citoplasma/metabolismo; Proteínas Ligadas por GPI/imunologia; Proteínas Ligadas por GPI/metabolismo; Humanos; Imunoconjugados/imunologia; Imuno-Histoquímica; Indóis/química; Indóis/farmacocinética; Masculino; Mesotelina; Camundongos Endogâmicos BALB C; Camundongos Nus; Microscopia de Fluorescência; Neoplasias Pancreáticas/diagnóstico por imagem; Neoplasias Pancreáticas/patologia; Tomografia por Emissão de Pósitrons/métodos; Radioisótopos/química; Radioisótopos/farmacocinética; Fatores de Tempo; Distribuição Tecidual; Transplante Heterólogo; Zircônio/química; Zircônio/farmacocinética

Palavras-chave

IRDye 800CW; PET imaging; mesothelin; pancreatic cancer; zirconium-89

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Imunoconjugados / Proteínas Ligadas por GPI / Anticorpos Monoclonais Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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