Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis.
Circ Res
; 118(1): 108-18, 2016 Jan 08.
Article
em En
| MEDLINE
| ID: mdl-26538569
ABSTRACT
Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is the transformation of fibroblasts into myofibroblasts, which secrete large amounts of extracellular matrix proteins. Although the function of protein-coding genes in myofibroblast activation and fibrosis have been a topic of investigation for a long time, it has become clear that noncoding RNAs also play key roles in cardiac fibrosis. This review discusses the involvement of microRNAs and long noncoding RNAs in cardiac fibrosis and summarizes the issues related to translating these findings into real-life therapies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA não Traduzido
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Cardiopatias
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Miocárdio
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article