Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes.
J Nat Prod
; 78(11): 2719-25, 2015 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-26539973
ABSTRACT
Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 µM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cianobactérias
/
Lipopeptídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article