Cytosolic phospholipase A2 &#945; has a crucial role in the pathogenesis of DSS-induced colitis in mice.

Rosengarten, Marina; Hadad, Nurit; Solomonov, Yulia; Lamprecht, Sergio; Levy, Rachel

Cytosolic phospholipase A2 α has a crucial role in the pathogenesis of DSS-induced colitis in mice.

Rosengarten, Marina; Hadad, Nurit; Solomonov, Yulia; Lamprecht, Sergio; Levy, Rachel.

Afiliação

Rosengarten M; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical University Center, Beer-Sheva, Israel.
Hadad N; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical University Center, Beer-Sheva, Israel.
Solomonov Y; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical University Center, Beer-Sheva, Israel.
Lamprecht S; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical University Center, Beer-Sheva, Israel.
Levy R; Immunology and Infectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical University Center, Beer-Sheva, Israel.

Eur J Immunol ; 46(2): 400-8, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26548451

Assuntos

Colite/imunologia; Fosfolipases A2 do Grupo IV/metabolismo; NF-kappa B/metabolismo; Neutrófilos/imunologia; Animais; Biomarcadores/metabolismo; Movimento Celular/genética; Células Cultivadas; Colite/induzido quimicamente; Colite/prevenção & controle; Sulfato de Dextrana/administração & dosagem; Fosfolipases A2 do Grupo IV/genética; Humanos; Mucosa Intestinal/fisiologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Modelos Animais; NF-kappa B/genética; Oligonucleotídeos Antissenso/administração & dosagem; Regulação para Cima/genética

Palavras-chave

COX-2; Cytosolic phospholipase A2α (cPLA2α); DAI: Disease Activity Index; DSS-induced colitis; Inflammatory bowel disease (IBD); Neutrophil â NF-κB; TNF-α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Colite / Fosfolipases A2 do Grupo IV / Neutrófilos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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