Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways.

Siddiqi, Aisha; Hasan, Syed Kazim; Nafees, Sana; Rashid, Summya; Saidullah, Bano; Sultana, Sarwat

Siddiqi, Aisha; Hasan, Syed Kazim; Nafees, Sana; Rashid, Summya; Saidullah, Bano; Sultana, Sarwat.

Afiliação

Siddiqi A; Discipline of Life Sciences, School of Sciences, Indira Gandhi National Open University, Maidan Garhi, New Delhi 110068, India.
Hasan SK; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.
Nafees S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.
Rashid S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.
Saidullah B; Discipline of Life Sciences, School of Sciences, Indira Gandhi National Open University, Maidan Garhi, New Delhi 110068, India.
Sultana S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India. Electronic address: sarwat786@rediffmail.com.

Exp Mol Pathol ; 99(3): 641-53, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26551080

Assuntos

Carcinogênese/efeitos dos fármacos; Carcinoma de Células Renais/prevenção & controle; Hesperidina/farmacologia; Neoplasias Renais/prevenção & controle; Estresse Oxidativo/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Carcinógenos/toxicidade; Carcinoma de Células Renais/induzido quimicamente; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Compostos Férricos/toxicidade; Imuno-Histoquímica; Neoplasias Renais/induzido quimicamente; Masculino; Ácido Nitrilotriacético/análogos & derivados; Ácido Nitrilotriacético/toxicidade; Ratos; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Apoptosis; Hesperidin; Nephrotoxicity; Oxidative stress; Renal carcinogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Estresse Oxidativo / Carcinogênese / Hesperidina / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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