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Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
McLaren, Paul J; Coulonges, Cedric; Bartha, István; Lenz, Tobias L; Deutsch, Aaron J; Bashirova, Arman; Buchbinder, Susan; Carrington, Mary N; Cossarizza, Andrea; Dalmau, Judith; De Luca, Andrea; Goedert, James J; Gurdasani, Deepti; Haas, David W; Herbeck, Joshua T; Johnson, Eric O; Kirk, Gregory D; Lambotte, Olivier; Luo, Ma; Mallal, Simon; van Manen, Daniëlle; Martinez-Picado, Javier; Meyer, Laurence; Miro, José M; Mullins, James I; Obel, Niels; Poli, Guido; Sandhu, Manjinder S; Schuitemaker, Hanneke; Shea, Patrick R; Theodorou, Ioannis; Walker, Bruce D; Weintrob, Amy C; Winkler, Cheryl A; Wolinsky, Steven M; Raychaudhuri, Soumya; Goldstein, David B; Telenti, Amalio; de Bakker, Paul I W; Zagury, Jean-François; Fellay, Jacques.
Afiliação
  • McLaren PJ; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;
  • Coulonges C; Laboratoire Génomique, Bioinformatique, et Applications, EA4627, Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, 75003 Paris, France; ANRS Genomic Group (French Agency for Research on AIDS and Hepatitis), 75013 Paris, France;
  • Bartha I; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;
  • Lenz TL; Evolutionary Immunogenomics, Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, 24306 Ploen, Germany;
  • Deutsch AJ; Harvard-MIT Division of Health Sciences and Technology and Harvard Medical School, Harvard University, Boston, MA 02115; Division of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; Program in Medical and Population Genetics, Broad Institute of MIT a
  • Bashirova A; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02129;
  • Buchbinder S; Bridge HIV-1, San Francisco Department of Public Health, San Francisco, CA 94102;
  • Carrington MN; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02129; Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Cossarizza A; Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine, 41121 Modena, Italy;
  • Dalmau J; AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain;
  • De Luca A; University Division of Infectious Diseases, Siena University Hospital, 53100 Siena, Italy; Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy;
  • Goedert JJ; Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850;
  • Gurdasani D; Human Genetics, Wellcome Trust Sanger Institute, CB10 1SA Hinxton, United Kingdom; Department of Medicine, University of Cambridge, CB2 2QQ Cambridge, United Kingdom;
  • Haas DW; Vanderbilt University School of Medicine, Nashville, TN 37212;
  • Herbeck JT; Department of Global Health, University of Washington, Seattle, WA 98195;
  • Johnson EO; Behavioral Health Epidemiology, RTI International, Research Triangle Park, NC 27709;
  • Kirk GD; Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205;
  • Lambotte O; INSERM U1012, 94270 Bicêtre, France; University Paris-Sud, 94270 Bicêtre, France; Assistance Publique-Hôpitaux de Paris, Department of Internal Medicine and Infectious Diseases, Bicêtre Hospital, 94270 Bicêtre, France;
  • Luo M; Department of Medical Microbiology, University of Manitoba, R3E 0J6 Winnipeg, MB, Canada; National Microbiology Laboratory, R3E 3P6 Winnipeg, MB, Canada;
  • Mallal S; Institute for Immunology & Infectious Diseases, Murdoch University and Pathwest, 6150 Perth, Australia;
  • van Manen D; Center for Infectious Diseases and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
  • Martinez-Picado J; AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain; Institució Catalana de Recerca i Estudis Avançats, 08916 Barcelona, Spain;
  • Meyer L; ANRS Genomic Group (French Agency for Research on AIDS and Hepatitis), 75013 Paris, France; Inserm, Centre de Recherche en Épidémiologie et Santé des Populations, U1018, Le Kremlin 94270 Bicêtre, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, UMRS 1018, Le Kremlin 94270 Bicêtre, France
  • Miro JM; Infectious Diseases Service, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain;
  • Mullins JI; Department of Microbiology, University of Washington, Seattle, WA 98195;
  • Obel N; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark;
  • Poli G; Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy;
  • Sandhu MS; Human Genetics, Wellcome Trust Sanger Institute, CB10 1SA Hinxton, United Kingdom; Department of Medicine, University of Cambridge, CB2 2QQ Cambridge, United Kingdom;
  • Schuitemaker H; Center for Infectious Diseases and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
  • Shea PR; Institute for Genomic Medicine, Columbia University, New York, NY 10032;
  • Theodorou I; ANRS Genomic Group (French Agency for Research on AIDS and Hepatitis), 75013 Paris, France; INSERM UMRS 945, 75014 Paris, France;
  • Walker BD; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02129; Howard Hughes Medical Institute, Chevy Chase, MD 20815;
  • Weintrob AC; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
  • Winkler CA; Basic Research Laboratory, Molecular Genetic Epidemiology Section, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702;
  • Wolinsky SM; Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;
  • Raychaudhuri S; Division of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142; Faculty of Medical and Human Sciences, University of Manchester, M13 9PL Manchester, Uni
  • Goldstein DB; Institute for Genomic Medicine, Columbia University, New York, NY 10032;
  • Telenti A; The J. Craig Venter Institute, La Jolla, CA 92037;
  • de Bakker PI; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands; Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Zagury JF; Laboratoire Génomique, Bioinformatique, et Applications, EA4627, Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, 75003 Paris, France; ANRS Genomic Group (French Agency for Research on AIDS and Hepatitis), 75013 Paris, France;
  • Fellay J; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Jacques.Fellay@epfl.ch.
Proc Natl Acad Sci U S A ; 112(47): 14658-63, 2015 Nov 24.
Article em En | MEDLINE | ID: mdl-26553974
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Carga Viral / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Interações Hospedeiro-Patógeno Limite: Adult / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Carga Viral / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Interações Hospedeiro-Patógeno Limite: Adult / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article