Evaluation of Risk Minimisation Measures for Blood Components - Based on Reporting Rates of Transfusion-Transmitted Reactions (1997-2013).
Transfus Med Hemother
; 42(4): 240-6, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26557816
ABSTRACT
BACKGROUND:
To assess the impact of safety measures, we compared reporting rates of transfusion-related reactions before and after the implementation of six measures in 1999, 2004, 2006, 2008 and 2009.METHODS:
Reporting rates of transfusion-transmitted bacterial infection (TTBI), viral infection (TTVI) and immune-mediated transfusion-related acute lung injury (TRALI) were calculated on the basis of confirmed annual reports and distributed blood components.RESULTS:
The introduction of HCV NAT testing caused a significant reduction of HCV reporting rate from 10.6 to 183.16 million administered blood components (p < 0.0001), donor screening for antibodies to hepatitis B core antigen caused a reduction of HBV reporting rate from 12.90 to 110.70 million units (p = 0.0168). A significant reduction from 10.094 to 12.42 million fresh frozen plasma (FFP) units could also be achieved by risk minimisation TRALI measures (p < 0.0001). Implementation of pre-donation sampling did not result in a significant decrease in TTBI, whereas limitation of shelf life for platelet concentrate (PC) minimised the TTBI reporting rate from 10.088 to 10.19 million PC units (p = 0.041). For HIV NAT pool testing, no significant reduction in HIV transmission was found due to very low reporting rates (110 million versus 127 million blood components, p = 0.422).CONCLUSION:
On the basis of haemovigilance data, a significant benefit could be demonstrated for four of six implemented safety measures.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article