Human Herpesvirus 6A U14 Is Important for Virus Maturation.
J Virol
; 90(3): 1677-81, 2016 02 01.
Article
em En
| MEDLINE
| ID: mdl-26559847
ABSTRACT
Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Proteínas Estruturais Virais
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Herpesvirus Humano 6
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article