Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet.

Kc, Ranjan; Li, Xin; Forsyth, Christopher B; Voigt, Robin M; Summa, Keith C; Vitaterna, Martha Hotz; Tryniszewska, Beata; Keshavarzian, Ali; Turek, Fred W; Meng, Qing-Jun; Im, Hee-Jeong

Kc, Ranjan; Li, Xin; Forsyth, Christopher B; Voigt, Robin M; Summa, Keith C; Vitaterna, Martha Hotz; Tryniszewska, Beata; Keshavarzian, Ali; Turek, Fred W; Meng, Qing-Jun; Im, Hee-Jeong.

Afiliação

Kc R; Departments of Biochemistry, Rush University Medical Center, Chicago, IL, 60612.
Li X; Departments of Biochemistry, Rush University Medical Center, Chicago, IL, 60612.
Forsyth CB; Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, 60612.
Voigt RM; Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, 60612.
Summa KC; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, 60208.
Vitaterna MH; Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, IL, 60208.
Tryniszewska B; Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, 60612.
Keshavarzian A; Division of Digestive Diseases and Nutrition, Rush University Medical Center, Chicago, IL, 60612.
Turek FW; Departments of Pharmacology, Rush University Medical Center, Chicago, IL, 60612.
Meng QJ; Departments of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL, 60612.
Im HJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Netherlands.

Sci Rep ; 5: 16896, 2015 Nov 20.

Article em En | MEDLINE | ID: mdl-26584570

Assuntos

Ritmo Circadiano; Dieta Hiperlipídica/efeitos adversos; Articulação do Joelho/patologia; Osteoartrite do Joelho/etiologia; Animais; Peso Corporal; Modelos Animais de Doenças; Progressão da Doença; Meio Ambiente; Humanos; Articulação do Joelho/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Obesidade/etiologia; Obesidade/fisiopatologia; Osteoartrite do Joelho/fisiopatologia; Proteoglicanas/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Osteoartrite do Joelho / Dieta Hiperlipídica / Articulação do Joelho Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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