Potent Antibody Protection against an Emerging Alphavirus Threat.

Kielian, Margaret; Saphire, Erica Ollmann

Kielian, Margaret; Saphire, Erica Ollmann.

Afiliação

Kielian M; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: margaret.kielian@einstein.yu.edu.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: erica@scripps.edu.

Cell ; 163(5): 1053-1054, 2015 Nov 19.

Article em En | MEDLINE | ID: mdl-26590413

ABSTRACT

ABSTRACT

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

Assuntos

Infecções por Alphavirus/imunologia; Alphavirus/imunologia; Anticorpos Monoclonais/imunologia; Anticorpos Neutralizantes/imunologia; Anticorpos Antivirais/imunologia; Epitopos; Proteínas do Envelope Viral/imunologia; Animais; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Infecções por Alphavirus / Alphavirus / Anticorpos Neutralizantes / Anticorpos Monoclonais / Anticorpos Antivirais / Epitopos Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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