Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.
Antimicrob Agents Chemother
; 60(2): 1141-4, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26596943
ABSTRACT
We compared the preclinical safety and efficacy of tenofovir (TFV) 1% gel with that of MZC gel [containing 50 µM MIV-150, 14 mM Zn(O2CCH3)2(H2O)2, and 3% carrageenan] through a series of in vitro, ex vivo, and in vivo assays. The two gels showed good antiviral therapeutic indexes (50% cytotoxic concentration/50% effective concentration ratios; range, >25 to 800). MZC showed greater anti-simian-human immunodeficiency virus reverse transcriptase (SHIV-RT) activity than TFV 1% gel in rhesus macaque vaginal explants. MZC protected mice from vaginal herpes simplex virus 2 (HSV-2) challenge (P < 0.0001), but the TFV 1% gel did not.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetato de Zinco
/
Antirretrovirais
/
Tenofovir
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article