Secondary vasculitis in autoimmune connective tissue diseases.

ABSTRACT

PURPOSE OF REVIEW The current review of the vasculitis associated with autoimmune connective tissue diseases is very appropriate and timely, in view of the recently acquired expanding knowledge, over the last decade, on the clinical epidemiology, pathophysiology, and the innovative therapeutic strategies. This review will specifically focus on the clinical presentations of secondary vasculitides, pathophysiology, and their management. RECENT FINDINGS: New knowledge on the immunological triggers and pathophysiology of these conditions, in relation to various infections and airborne substances are discussed apart from the novel targeted immunotherapy, which has a direct effect on the outcome and reduction of iatrogenic complications. IN SUMMARY: The review will inform the classical nature and pattern of vasculitis secondary to autoimmune diseases with specific reference to targeted immunotherapy.