Scanned ion beam therapy for prostate carcinoma: Comparison of single plan treatment and daily plan-adapted treatment.
Strahlenther Onkol
; 192(2): 118-26, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26614393
ABSTRACT
BACKGROUND AND PURPOSE:
Intensity-modulated particle therapy (IMPT) for tumors showing interfraction motion is a topic of current research. The purpose of this work is to compare three treatment strategies for IMPT to determine potential advantages and disadvantages of ion prostate cancer therapy. MATERIALS ANDMETHODS:
Simulations for three treatment strategies, conventional one-plan radiotherapy (ConvRT), image-guided radiotherapy (IGRT), and online adaptive radiotherapy (ART) were performed employing a dataset of 10 prostate cancer patients with six CT scans taken at one week intervals. The simulation results, using a geometric margin concept (7-2 mm) as well as patient-specific internal target volume definitions for IMPT were analyzed by target coverage and exposure of critical structures on single fraction dose distributions.RESULTS:
All strategies led to clinically acceptable target coverage in patients exhibiting small prostate motion (mean displacement <4 mm), but IGRT and especially ART led to significant sparing of the rectum. In 20% of the patients, prostate motion exceeded 4 mm causing insufficient target coverage for ConvRT (V95mean = 0.86, range 0.63-0.99) and IGRT (V95mean = 0.91, range 0.68-1.00), while ART maintained acceptable target coverage.CONCLUSION:
IMPT of prostate cancer demands consideration of rectal sparing and adaptive treatment replanning for patients exhibiting large prostate motion.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Planejamento da Radioterapia Assistida por Computador
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Tomografia Computadorizada por Raios X
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Monitoramento de Radiação
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Fracionamento da Dose de Radiação
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Radioterapia de Intensidade Modulada
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Erros de Configuração em Radioterapia
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Radioterapia Guiada por Imagem
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Radioterapia com Íons Pesados
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Movimento (Física)
Tipo de estudo:
Etiology_studies
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article