A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells.

Wani, Zahoor Ahmad; Guru, Santosh Kumar; Rao, A V Subba; Sharma, Sonia; Mahajan, Girish; Behl, Akanksha; Kumar, Ashok; Sharma, P R; Kamal, Ahmed; Bhushan, Shashi; Mondhe, Dilip M

A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells.

Wani, Zahoor Ahmad; Guru, Santosh Kumar; Rao, A V Subba; Sharma, Sonia; Mahajan, Girish; Behl, Akanksha; Kumar, Ashok; Sharma, P R; Kamal, Ahmed; Bhushan, Shashi; Mondhe, Dilip M.

Afiliação

Wani ZA; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Guru SK; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Rao AV; Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Sharma S; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Mahajan G; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Behl A; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Kumar A; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Sharma PR; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Kamal A; Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Bhushan S; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India. Electronic address: sbhushan@iiim.ac.in.
Mondhe DM; Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India. Electronic address: dmmondhe@iiim.ac.in.

Food Chem Toxicol ; 87: 1-11, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26615871

Assuntos

Apoptose/efeitos dos fármacos; Chalconas/farmacologia; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Quinazolinonas/farmacologia; Serina-Treonina Quinases TOR/metabolismo; Animais; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Chalconas/química; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Estrutura Molecular; Neoplasias Experimentais/tratamento farmacológico; Fosfatidilinositol 3-Quinases/genética; Proteínas Proto-Oncogênicas c-akt/genética; Quinazolinonas/química; Distribuição Aleatória; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/genética

Palavras-chave

Apoptosis; PI3K/Akt/mTOR; Quinazolinone-chalcone; Sarcoma-180

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Fosfatidilinositol 3-Quinases / Chalconas / Proteínas Proto-Oncogênicas c-akt / Quinazolinonas / Serina-Treonina Quinases TOR Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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