Heat-labile enterotoxin of Escherichia coli promotes intestinal colonization of Salmonella enterica.
Comp Immunol Microbiol Infect Dis
; 43: 1-7, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26616654
ABSTRACT
Enterotoxigenic Escherichia coli (ETEC) is an important cause of infantile and travellers' diarrhoea, which poses a serious health burden, especially in developing countries. In addition, ETEC bacteria are a major cause of illness and death in neonatal and recently weaned pigs. The production of a heat-labile enterotoxin (LT) promotes the colonization and pathogenicity of ETEC and may exacerbate co-infections with other enteric pathogens such as Salmonella enterica. We showed that the intraintestinal presence of LT dramatically increased the intestinal Salmonella Typhimurium load in experimentally inoculated pigs. This could not be explained by direct alteration of the invasion or survival capacity of Salmonella in enterocytes, in vitro. However, we demonstrated that LT affects the enteric mucus layer composition in a mucus-secreting goblet cell line by significantly decreasing the expression of mucin 4. The current results show that LT alters the intestinal mucus composition and aggravates a Salmonella Typhimurium infection, which may result in the exacerbation of the diarrhoeal illness.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Salmonelose Animal
/
Salmonella typhimurium
/
Toxinas Bacterianas
/
Proteínas de Escherichia coli
/
Diarreia
/
Enterotoxinas
/
Escherichia coli Enterotoxigênica
/
Intestinos
/
Muco
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article