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Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.
Bhatt, Nikunj; Soni, Nisarg; Ha, Yeong Su; Lee, Woonghee; Pandya, Darpan N; Sarkar, Swarbhanu; Kim, Jung Young; Lee, Hochun; Kim, Sun Hee; An, Gwang Il; Yoo, Jeongsoo.
Afiliação
  • Bhatt N; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Soni N; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Ha YS; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Lee W; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Pandya DN; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Sarkar S; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
  • Kim JY; Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
  • Lee H; Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science & Technology , Daegu 711-873, South Korea.
  • Kim SH; Western Seoul Center, Korea Basic Science Institute , Seoul 120-140, Korea.
  • An GI; Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
  • Yoo J; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
ACS Med Chem Lett ; 6(11): 1162-6, 2015 Nov 12.
Article em En | MEDLINE | ID: mdl-26617972
ABSTRACT
A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, (64)Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article