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Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations.
Uth, Jacob; Hornstrup, Therese; Christensen, Jesper F; Christensen, Karl B; Jørgensen, Niklas R; Helge, Eva W; Schmidt, Jakob F; Brasso, Klaus; Helge, Jørn W; Jakobsen, Markus D; Andersen, Lars L; Rørth, Mikael; Midtgaard, Julie; Krustrup, Peter.
Afiliação
  • Uth J; University Hospitals Centre for Health Research (UCSF), Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark. ju@ucsf.dk.
  • Hornstrup T; Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and Health, University of Copenhagen, Nørre Allé 51, Copenhagen, 2200, Denmark.
  • Christensen JF; Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
  • Christensen KB; Department of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, 1014, Denmark.
  • Jørgensen NR; Department of Clinical Biochemistry, Rigshospitalet, Research Center for Ageing and Osteoporosis, Ndr. Ringvej 57, Glostrup, 2600, Denmark.
  • Helge EW; Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, Odense, 5000, Denmark.
  • Schmidt JF; Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and Health, University of Copenhagen, Nørre Allé 51, Copenhagen, 2200, Denmark.
  • Brasso K; Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and Health, University of Copenhagen, Nørre Allé 51, Copenhagen, 2200, Denmark.
  • Helge JW; Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
  • Jakobsen MD; Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
  • Andersen LL; National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, 2100, Denmark.
  • Rørth M; National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, 2100, Denmark.
  • Midtgaard J; Physical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, 9220, Aalborg, Denmark.
  • Krustrup P; Department of Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, 2100, Denmark.
Eur J Appl Physiol ; 116(3): 471-80, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26620651
PURPOSE: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). METHODS: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. RESULTS: In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8-46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes. CONCLUSION: Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01711892.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adaptação Fisiológica / Músculo Esquelético / Antineoplásicos Hormonais / Equilíbrio Postural / Terapia por Exercício / Futebol Americano / Antagonistas de Androgênios Tipo de estudo: Clinical_trials Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adaptação Fisiológica / Músculo Esquelético / Antineoplásicos Hormonais / Equilíbrio Postural / Terapia por Exercício / Futebol Americano / Antagonistas de Androgênios Tipo de estudo: Clinical_trials Limite: Aged / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article