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M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.
Garcia, Raphael Caio Tamborelli; Dati, Livia Mendonça Munhoz; Torres, Larissa Helena; da Silva, Mariana Aguilera Alencar; Udo, Mariana Sayuri Berto; Abdalla, Fernando Maurício Francis; da Costa, José Luiz; Gorjão, Renata; Afeche, Solange Castro; Yonamine, Mauricio; Niswender, Colleen M; Conn, P Jeffrey; Camarini, Rosana; Sandoval, Maria Regina Lopes; Marcourakis, Tania.
Afiliação
  • Garcia RC; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • Dati LM; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, 1° andar, 09913-030, Diadema/SP, Brazil.
  • Torres LH; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
  • da Silva MA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, 2201 West End Avenue, 1205 Light Hall, 37232-0697, Nashville/TN, USA.
  • Udo MS; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • Abdalla FM; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • da Costa JL; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • Gorjão R; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • Afeche SC; Laboratory of Pharmacology, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo/SP, Brazil.
  • Yonamine M; Criminalistic Institute of São Paulo, Rua Moncorvo Filho, 410, 05507-060, São Paulo/SP, Brazil.
  • Niswender CM; Institute of Physical Activity Sciences and Sports, Post-Graduate Program in Human Movement Sciences, Cruzeiro do Sul University, São Paulo, Brazil.
  • Conn PJ; Laboratory of Pharmacology, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo/SP, Brazil.
  • Camarini R; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo/SP, Brazil.
  • Sandoval MR; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
  • Marcourakis T; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, 2201 West End Avenue, 1205 Light Hall, 37232-0697, Nashville/TN, USA.
Sci Rep ; 5: 17555, 2015 Dec 02.
Article em En | MEDLINE | ID: mdl-26626425
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cocaína / Síndromes Neurotóxicas / Receptor Muscarínico M1 / Receptor Muscarínico M3 / Hipocampo / Neurotoxinas Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cocaína / Síndromes Neurotóxicas / Receptor Muscarínico M1 / Receptor Muscarínico M3 / Hipocampo / Neurotoxinas Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article