Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis.

Lin, Joseph B; Mast, Natalia; Bederman, Ilya R; Li, Yong; Brunengraber, Henri; Björkhem, Ingemar; Pikuleva, Irina A

Lin, Joseph B; Mast, Natalia; Bederman, Ilya R; Li, Yong; Brunengraber, Henri; Björkhem, Ingemar; Pikuleva, Irina A.

Afiliação

Lin JB; Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Cleveland, OH 44106.
Mast N; Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Cleveland, OH 44106.
Bederman IR; Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.
Li Y; Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Cleveland, OH 44106.
Brunengraber H; Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106.
Björkhem I; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Karolinska Institute, Huddinge, Stockholm 141 86 Sweden.
Pikuleva IA; Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Cleveland, OH 44106 iap8@case.edu.

J Lipid Res ; 57(2): 258-64, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26630912

Assuntos

Colesterol/biossíntese; Degeneração Macular/metabolismo; Retina/metabolismo; Animais; Colesterol/metabolismo; Humanos; Degeneração Macular/patologia; Degeneração Macular/terapia; Camundongos

Palavras-chave

age-related macular degeneration; brain lipids; cholesterol uptake; deuterium; dietary cholesterol; isotopic tracer; lipoproteins; low density lipoprotein; mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Colesterol / Degeneração Macular Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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