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Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.
Li, Yuexian; Woo, Jiyeon; Chmielecki, Jessica; Xia, Cindy Q; Liao, Mingxiang; Chuang, Bei-Ching; Yang, Johnny J; Guan, Miao Y; Plesescu, Mihaela; Prakash, Shimoga R.
Afiliação
  • Li Y; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA. Electronic address: yuexianfrank.li@takeda.com.
  • Woo J; Boston University, 881 Commonwealth Avenue, Boston, MA 02215, USA.
  • Chmielecki J; Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
  • Xia CQ; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Liao M; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Chuang BC; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Yang JJ; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Guan MY; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Plesescu M; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
  • Prakash SR; Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., 35 Landsdowne Street, Cambridge, MA 02139, USA.
Bioorg Med Chem Lett ; 26(2): 551-555, 2016 Jan 15.
Article em En | MEDLINE | ID: mdl-26642765
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dicetopiperazinas / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Compostos Heterocíclicos de 4 ou mais Anéis Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dicetopiperazinas / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Compostos Heterocíclicos de 4 ou mais Anéis Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article