Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNÎ³ Autoantibodies.

Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini; Barber, Daniel L; Chen, Ray Y; Hsu, Denise C; Qasba, S Sonia; Zerbe, Christa S; Holland, Steven M; Browne, Sarah K

Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini; Barber, Daniel L; Chen, Ray Y; Hsu, Denise C; Qasba, S Sonia; Zerbe, Christa S; Holland, Steven M; Browne, Sarah K.

Afiliação

Xie YL; Laboratory of Clinical Infectious Diseases.
Rosen LB; Laboratory of Clinical Infectious Diseases.
Sereti I; Laboratory of Immunoregulation.
Barber DL; Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda.
Chen RY; Laboratory of Clinical Infectious Diseases.
Hsu DC; Laboratory of Immunoregulation.
Qasba SS; Montgomery County Health Department, Silver Spring, Maryland.
Zerbe CS; Laboratory of Clinical Infectious Diseases.
Holland SM; Laboratory of Clinical Infectious Diseases.
Browne SK; Laboratory of Clinical Infectious Diseases.

Clin Infect Dis ; 62(6): 770-773, 2016 Mar 15.

Article em En | MEDLINE | ID: mdl-26646678

ABSTRACT

ABSTRACT

Interferon-gamma (IFNÎ³) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNÎ³-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNÎ³ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.

Assuntos

Antibacterianos/efeitos adversos; Anticorpos Neutralizantes/biossíntese; Autoanticorpos/sangue; Interferon gama/imunologia; Tuberculose Miliar/imunologia; Antibacterianos/administração & dosagem; Autoanticorpos/imunologia; Feminino; Humanos; Imunoglobulina G/imunologia; Inflamação/imunologia; Inflamação/microbiologia; Interferon gama/sangue; Pessoa de Meia-Idade; Tuberculose Miliar/tratamento farmacológico; Tuberculose Miliar/etnologia; Estados Unidos

Palavras-chave

IRIS; autoantibodies; disseminated tuberculosis; interferon-gamma; paradoxical reaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Tuberculose Miliar / Interferon gama / Anticorpos Neutralizantes / Antibacterianos Limite: Female / Humans / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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