Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity.
J Virol
; 90(4): 2135-41, 2016 02 15.
Article
em En
| MEDLINE
| ID: mdl-26656695
ABSTRACT
Protein kinase R (PKR) and RNase L are host cell components that function to contain viral spread after infections. In this study, we analyzed the role of both proteins in the abortive infection of human HeLa cells with the poxvirus strain NYVAC, for which an inhibition of viral A27L and B5R gene expression is described. Specifically, the translation of these viral genes is independent of PKR activation, but their expression is dependent on the RNase L activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vaccinia virus
/
Proteínas Virais
/
Glicoproteínas de Membrana
/
Proteínas do Envelope Viral
/
EIF-2 Quinase
/
Endorribonucleases
/
Células Epiteliais
/
Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article