Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs.

Corsiero, Elisa; Bombardieri, Michele; Carlotti, Emanuela; Pratesi, Federico; Robinson, William; Migliorini, Paola; Pitzalis, Costantino

Corsiero, Elisa; Bombardieri, Michele; Carlotti, Emanuela; Pratesi, Federico; Robinson, William; Migliorini, Paola; Pitzalis, Costantino.

Afiliação

Corsiero E; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Bombardieri M; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Carlotti E; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Pratesi F; Clinical Immunology and Allergy Unit, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
Robinson W; Stanford University School of Medicine, Stanford, USA.
Migliorini P; Clinical Immunology and Allergy Unit, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
Pitzalis C; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

Ann Rheum Dis ; 75(10): 1866-75, 2016 10.

Article em En | MEDLINE | ID: mdl-26659717

Assuntos

Anticorpos Monoclonais/metabolismo; Artrite Reumatoide/imunologia; Linfócitos B/imunologia; Armadilhas Extracelulares/imunologia; Histonas/imunologia; Idoso; Autoanticorpos/imunologia; Autoantígenos/imunologia; Autoantígenos/metabolismo; Autoimunidade; Citrulina/imunologia; Feminino; Humanos; Articulações/imunologia; Articulações/metabolismo; Pessoa de Meia-Idade; Membrana Sinovial/imunologia

Palavras-chave

Autoantibodies; B cells; Rheumatoid Arthritis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Linfócitos B / Histonas / Armadilhas Extracelulares / Anticorpos Monoclonais Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google