The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations.
Eur Radiol
; 26(8): 2646-55, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-26670320
ABSTRACT
OBJECTIVES:
To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations.METHODS:
Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated.RESULTS:
SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models.CONCLUSION:
Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. KEY POINTS ⢠Blood dose can be simulated using the patient's clinical CT images. ⢠SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. ⢠SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pelve
/
Doses de Radiação
/
Tórax
/
Tomografia Computadorizada por Raios X
/
Abdome
/
Órgãos em Risco
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Etiology_studies
/
Health_economic_evaluation
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article