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The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.
Erazo, Tatiana; Lorente, Mar; López-Plana, Anna; Muñoz-Guardiola, Pau; Fernández-Nogueira, Patricia; García-Martínez, José A; Bragado, Paloma; Fuster, Gemma; Salazar, María; Espadaler, Jordi; Hernández-Losa, Javier; Bayascas, Jose Ramon; Cortal, Marc; Vidal, Laura; Gascón, Pedro; Gómez-Ferreria, Mariana; Alfón, José; Velasco, Guillermo; Domènech, Carles; Lizcano, Jose M.
Afiliação
  • Erazo T; Protein Kinases and Signal Transduction Laboratory, Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
  • Lorente M; Department of Biochemistry and Molecular Biology, Faculty of Biology, Universidad Complutense, Madrid, Spain. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
  • López-Plana A; Area of Molecular and Translational Oncology, IDIBAPS, Fundació Clínic, Universitat de Barcelona, Barcelona, Spain.
  • Muñoz-Guardiola P; Protein Kinases and Signal Transduction Laboratory, Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Fernández-Nogueira P; Area of Molecular and Translational Oncology, IDIBAPS, Fundació Clínic, Universitat de Barcelona, Barcelona, Spain.
  • García-Martínez JA; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Bragado P; Area of Molecular and Translational Oncology, IDIBAPS, Fundació Clínic, Universitat de Barcelona, Barcelona, Spain.
  • Fuster G; Area of Molecular and Translational Oncology, IDIBAPS, Fundació Clínic, Universitat de Barcelona, Barcelona, Spain.
  • Salazar M; Department of Biochemistry and Molecular Biology, Faculty of Biology, Universidad Complutense, Madrid, Spain.
  • Espadaler J; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Hernández-Losa J; Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Bayascas JR; Institut de Neurociències and Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Cortal M; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Vidal L; Medical Oncology Department, Novel Therapeutics Unit, Hospital Clínic Barcelona. Barcelona, Catalonia, Spain.
  • Gascón P; Area of Molecular and Translational Oncology, IDIBAPS, Fundació Clínic, Universitat de Barcelona, Barcelona, Spain. Medical Oncology Department, Novel Therapeutics Unit, Hospital Clínic Barcelona. Barcelona, Catalonia, Spain.
  • Gómez-Ferreria M; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Alfón J; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Velasco G; Department of Biochemistry and Molecular Biology, Faculty of Biology, Universidad Complutense, Madrid, Spain. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
  • Domènech C; Ability Pharmaceuticals, SL, Edifici Eureka, Campus UAB, Bellaterra, Barcelona, Catalonia, Spain.
  • Lizcano JM; Protein Kinases and Signal Transduction Laboratory, Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. josemiguel.lizcano@uab.es.
Clin Cancer Res ; 22(10): 2508-19, 2016 05 15.
Article em En | MEDLINE | ID: mdl-26671995
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação para Cima / Proteínas de Ciclo Celular / Proteínas Proto-Oncogênicas c-akt / Alvo Mecanístico do Complexo 1 de Rapamicina / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação para Cima / Proteínas de Ciclo Celular / Proteínas Proto-Oncogênicas c-akt / Alvo Mecanístico do Complexo 1 de Rapamicina / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article