Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen, Su Duy; Maaninka, Katariina; Lappalainen, Jani; Nurmi, Katariina; Metso, Jari; Öörni, Katariina; Navab, Mohamad; Fogelman, Alan M; Jauhiainen, Matti; Lee-Rueckert, Miriam; Kovanen, Petri T

Nguyen, Su Duy; Maaninka, Katariina; Lappalainen, Jani; Nurmi, Katariina; Metso, Jari; Öörni, Katariina; Navab, Mohamad; Fogelman, Alan M; Jauhiainen, Matti; Lee-Rueckert, Miriam; Kovanen, Petri T.

Afiliação

Nguyen SD; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Maaninka K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Lappalainen J; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Nurmi K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Metso J; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Öörni K; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Navab M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Fogelman AM; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Jauhiainen M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Lee-Rueckert M; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici
Kovanen PT; From the Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (S.D.N., K.M., J.L., K.N., K.Ö., M.L.-R., P.T.K.); National Institute for Health and Welfare, Genomics and Biomarkers Unit, Biomedicum Helsinki, Helsinki, Finland (J.M., M.J.); and Division of Cardiology, Department of Medici

Arterioscler Thromb Vasc Biol ; 36(2): 274-84, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26681753

Assuntos

Apolipoproteína A-I/metabolismo; Aterosclerose/enzimologia; Quimases/metabolismo; Células Endoteliais/metabolismo; Inflamação/enzimologia; Mastócitos/enzimologia; Apolipoproteína A-I/farmacologia; Aterosclerose/imunologia; Aterosclerose/prevenção & controle; Adesão Celular; Linhagem Celular Tumoral; Colesterol/metabolismo; Técnicas de Cocultura; Citocinas/metabolismo; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/imunologia; Células Espumosas/imunologia; Células Espumosas/metabolismo; Humanos; Inflamação/imunologia; Inflamação/prevenção & controle; Mediadores da Inflamação/metabolismo; Mastócitos/efeitos dos fármacos; Mastócitos/imunologia; NF-kappa B/metabolismo; Ativação de Neutrófilo; Neutrófilos/imunologia; Neutrófilos/metabolismo; Peptídeos/farmacologia; Estrutura Terciária de Proteína; Proteólise; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Migração Transendotelial e Transepitelial; Molécula 1 de Adesão de Célula Vascular/metabolismo

Palavras-chave

apolipoprotein A-I; carboxyl-terminal cleavage; chymase; endothelial cells; inflammatory; mast cell; proteases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteína A-I / Células Endoteliais / Aterosclerose / Quimases / Inflamação / Mastócitos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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