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Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
Singh, Bishal Kumar; Koromyslova, Anna; Hefele, Lisa; Gürth, Clara; Hansman, Grant S.
Afiliação
  • Singh BK; Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
  • Koromyslova A; Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
  • Hefele L; Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
  • Gürth C; Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
  • Hansman GS; Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany g.hansman@dkfz.de.
J Virol ; 90(5): 2710-5, 2015 Dec 23.
Article em En | MEDLINE | ID: mdl-26699640
ABSTRACT
Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Capsídeo / Infecções por Caliciviridae / Evolução Molecular / Norovirus / Genótipo Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Variação Genética / Capsídeo / Infecções por Caliciviridae / Evolução Molecular / Norovirus / Genótipo Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article